|
|
Hotels: types of mesothelioma |
|
|
|
Colon Cancer and Nutrition
Colon Cancer also known Colorectal cancer. Colon cancer 2nd most deaths for cancers in the US. Colon cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). The colon is the part of the digestive system where the waste material is stored. The rectum is the end of the colon adjacent to the anus. Together, they form a long, muscular tube called the large intestine (also known as the large bowel). Tumors of the colon and rectum are growths arising from the inner wall of the large intestine. Benign tumors of the large intestine are called polyps. Cancer of the colon or rectum is also called colorectal cancer. In the United States, it is the fourth most common cancer in men and women. It is the third most common form of cancer and the second leading cause of cancer-related death in the Western world. Colorectal cancer causes 655,000 deaths worldwide per year.Many colorectal cancers are thought to arise from adenomatous polyps in the colon. These mushroom-like growths are usually benign, but some may develop into cancer over time.
Colon cancer often causes no symptoms until it has reached a relatively advanced stage. Thus, many organizations recommend periodic screening for the disease with fecal occult blood testing and colonoscopy. It is common in the Western world, and is rare in Asia and Africa. In countries where the people have adopted western diets, the incidence of colorectal cancer is increasing. Most cases of colon cancer begin as small, noncancerous (benign) clumps of cells called adenomatous polyps. Polyps of the colon and rectum are almost always benign and usually produce no symptoms. They may, however, cause painless rectal bleeding or bleeding not apparent to the naked eye. There may be single or multiple polyps. Polyps greater than 1 centimeter have a greater cancer risk associated with them than polyps under 1 centimeter. Polyps with atypia or dysplasia are also more likely to progress on to colon cancer. The risk of cancer is much higher in sessile villous adenomas than in pedunculated tubular adenomas. Cancer is found in 40% of villous adenomas, as compared to 15% in tubular adenomas.
Chemotherapy is also used to treat patients with stage IV colon cancer. Surgery remains the primary treatment while chemotherapy and/or radiotherapy may be recommended depending on the individual patient's staging. High-fiber foods help move waste through your digestive tract faster, so harmful substances don’t have much contact with the lining of the intestine. High-fiber foods are also rich in phytonutrients, which appear to protect against several forms of cancer. Calcium and vitamin D also seem to help protect against colorectal cancer. There is certainly just as much buzz about folate and colorectal cancer prevention as there has been about calcium. The jury is still out on antioxidants and the prevention of colorectal cancer. Taking antioxidants, such as vitamin C or carotenoids, may reduce cancer risk but other studies have failed to back up these results. Vegetables high in folate, like leafy greens, seem to offer particular protection from colon cancer, especially for those who drink alcohol. Cruciferous vegetables, like broccoli and cauliflower, also contain phytochemicals that may prevent damage to colon cells.
Colon Cancer Treatment and Nutrition Tips
1. Chemotherapy is also used to treat patients with stage IV colon cancer.
2. Radiotherapy may be recommended Treatment fot colon cancer.
3. High-fiber foods help move waste through your digestive tract faster.
4. Calcium and vitamin D also seem to help protect against colorectal cancer.
5. Taking antioxidants, such as vitamin C or carotenoids, may reduce cancer risk but other studies have failed to back up these results.
6. Vegetables high in folate, like leafy greens, seem to offer particular protection from colon cancer, especially for those who drink alcohol.
7. Cruciferous vegetables, like broccoli and cauliflower, also contain phytochemicals that may prevent damage to colon cells.
Using A Real Estate Attorney in For Sale By Owner Transactions
Even though you are selling your home without an agent, the assistance of a professional is still needed at various steps in the home selling process. The requirement of a real estate attorney depends on the laws in your state. Even if you live in a state where a real estate attorney is not needed, as a for sale by owner seller, it will still be beneficial for you to use one.
An attorney can serve many purposes in the housing transaction. When you hire an attorney that specialized in real estate, that attorney is responsible for seeing that your best interests are met in the housing transaction. An attorney can act as the escrow agent by holding down payments, documentation, and earnest money deposits. Not only that, the attorney can help you decipher and evaluate complicated offers you might receive from a buyer. In the event that the lenders attorney does not handle the closing, your attorney will host and handle the closing. If the lenders attorney does handle the closing, then your real attorney will represent you in the process.
Your primary concern should be to find a real estate attorney that will provide you with assistance you need in the housing transaction. You can use a local or internet directory to find the names of some attorneys in your area. Asking friends or family who have recently sold homes for references is another way that you can find an attorney to assist you. If there are neighbors with for sale signs in their yards, you can casually inquire about the attorney they are using. Hiring an attorney that comes as a reference is often better than cold calling attorneys.
As you look for an attorney to hire, you should choose one that works primarily with real estate transactions. Avoid choosing a criminal or family law attorney that handles real estate transactions on the side. Your interests will not be best served by an attorney that does not spend a significant part of his or her time in real estate transactions. Certainly do not hire an attorney that has never worked in real estate.
Along with experience in real estate transactions, price will be the other factor you use to choose a real estate attorney. The attorney you hire will have two major responsibilities: reading and advising you on documents and representing you at closing. Get a price quote from prospective attorneys on those two tasks. You can get a discount from the attorney by letting him or her know that you will be preparing and filling out some of the documentation. Shop around among several attorneys to get a feel for experience level and price charged.
The most important thing is that you have a real estate professional available to assist you through the transaction. Even if you have successfully sold a for sale by owner home before, it is better to have legal assistance than to attempt to complete the process on your own.
How to Find a Good Attorney
The question of how to find a good attorney is on everyone's mind when in need of a lawyer. And it's difficult for an ordinary person to know how to find a good attorney. The legal profession is just like any other profession where you have good, disciplined and honest members as well as bad, not disciplined and dishonest ones. And in the legal profession, unfortunately, only fellow attorneys and judges know who is who. That leaves us, the ordinary people, to learn as best as we could on ways of how to find a good attorney to represent our case.
When faced with a legal issue that requires lawyer's participation, the only thing worse than not having a lawyer is to have a bad one. However, the "good" and the "bad" labels are a subject to a personal judgment. As mentioned above, while only fellow attorneys and judges know who is the good, the bad, and the ugly attorney, in the ordinary human world, two people could share a totally opposite opinion about one attorney who represented both of their cases. It's all based on the results that the attorney was able to obtain for them and whether the clients' expectations were met or not. This leads us to a conclusion that when we have a lack of resources to evaluate our prospect attorneys, we need to depend solely upon our individual judgment to pick a good attorney for our case.
On the other hand, there are ways to at least sense a bad attorney. Wait! Isn't it the subject of this article "How to find a good attorney"? Indeed so. In order for you to know how to find a good attorney, you need to know how to at least sense a bad one. Let's touch up on some basics.
1. Very simple. If you need to file for a divorce, would you call a criminal lawyer? Of course not. That's a bad lawyer for your case. On the same note, if other than a divorce lawyer is offering to handle your case, you would say no. You immediately know that a good lawyer for your case would be the one who has expertise in whatever legal issue you're facing.
2. You somehow find a lawyer that has the expertise in your problem area and you make a contact with him or her. But, it takes that lawyer a week or two to get back to you. That attorney may not be a bad lawyer but he or she may be overbooked with other clients and does not have enough time to give the needed attention to your case. That's a bad lawyer for your case. That attorney needs to immediately tell you that because of their current work load he or she wouldn't be able to handle your case. But if he or she doesn't tell you that, you need to immediately dismiss that attorney and look for another one who can give you the needed attention.
3. Here comes the bad one. It is highly unethical for a lawyer to pay a referral fee or a bonus for "leads" on new cases. (Depending on state law, a referral fee sometimes may be paid to another lawyer, but it needs to be disclosed to the client). Some of the profession's "bad apples" may still engage in the practice of paying "runners" for tips on new clients. So if a stranger (or even someone that you know) seems excessively persistent that you need to see a lawyer, or just happens to have a supply of the attorney's business cards, look out! This is not the kind of person who deserves your trust. On the same note, if you bump into a lawyer who does not take his or her time to understand your case but is also excessively persistent that you need to hire him or her, look out!
Now, let's cover some basics on ways of how to find a good attorney.
1. One of the best ways on how to find a good attorney is to ask someone whose opinion you trust; another lawyer, your accountant, banker, coworker, family friend, business acquaintance. These are the people that you trust and you know that they wouldn't refer you to a bad lawyer if they happen to know one related to your legal need.
2. If the above doesn't work for you, you could always call a company that may be represented by a lawyer of your need. For an example, if you're looking for a real estate lawyer, call a title company and ask them who they use. If you need a collection lawyer, call a collection agency. But, if your issue is pure personal, ask anyone who you trust, who has recently been through a lawsuit, and who is very satisfied with their lawyer. Even if that lawyer is not the right one for your case, you know that you're contacting a good lawyer. Call that lawyer and explain that you couldn't find an attorney on your own and ask him or her if they could refer you to the appropriate attorney for your case. Lawyers are the best source of information about other lawyers. And a good lawyer will always refer you to another good lawyer who could handle your case.
3. And last but not least on how to find a good lawyer, call your local or state bar association and ask them to refer you to a lawyer who is in good standing with the bar. Also, always check with your state or local bar association if your prospect lawyer has ever been the subject of an ethical complaint or inquiry.
To sum up the ways on how to find a good attorney, the primary considerations in selecting an attorney needs to be whether you feel comfortable with the attorney selected, and if you are confident that the attorney is competent in his or her field of expertise. You must feel very comfortable with the attorney and must feel confident that the attorney selected is the one who can capably handle your needs. Make sure that you interview two or three lawyers before making a decision on which one to retain. Ask yourself when interviewing a lawyer: "Do I feel comfortable talking to this lawyer, and am I confident in his or her abilities?" If the answer is anything other than a definite "yes," you need to keep looking. Your case is too important to entrust to someone who does not inspire your confidence.
Disclaimer: The author and publisher of this article have done their best to give you useful, informative and accurate information. This article does not represent nor replace the legal advice you need to get from a lawyer, or other professional if the content of the article involves an issue you are facing. Laws vary from state-to-state and change from time-to-time. Always consult with a qualified professional before making any decisions about the issues described in this article. Thank you.
How to Choose a Lawyer: Referral Attorneys
When selecting an attorney, there are a number of important factors to consider. This article focuses on one: is the attorney you have contacted a "referral attorney"? Referral attorneys are attorneys who advertise to attract clients, but do not represent clients themselves. Instead, they forward the client on to another attorney. A typical referral attorney takes a fee as a percentage of the total recovery.
Is my attorney a referral attorney?
This is a simple question to answer - just ask them. A referral attorney will always, at some point, have to disclose that they will not be the primary attorney on your case. They will eventually be forwarding you on to another lawyer. Generally, if your attorney is advertising on television or has run ads seeking victims of injuries caused by a specific product (Vioxx cases, asbestos or mesothelioma cases, diet drug cases, or other class action lawsuits), then they are probably a referral attorney.
Will it cost me more money if I have contacted a referral attorney?
Generally, no. The typical agreement between a referral attorney and the actual lawyer working on the case grants the referral attorney a percentage of the actual lawyer's fee. Instead of coming from the client, the money comes from the lawyer who eventually is the attorney on the case. However, you should make sure that this is what your actual agreement is. A typical contingent fee case costs the client one third of the recovery. If you have contacted a referral attorney, ask what the ultimate percentage will be.
Why even bother with a referral attorney if I'm going to someone else anyway?
If you know an attorney who is an expert in the field or who is handling that kind of case, there is generally no reason to. However, many people have absolutely no knowledge of the legal industry. They simply can't find an appropriate attorney on their own. A referral attorney usually only makes money if you win, so he will have an incentive to forward your case to a competent lawyer. Just make sure that you aren't being charged more for a referral - it's not worth paying extra to get it, especially because many other lawyers would be eager to point you to competent counsel for a cut themselves.
Cancer Prevention - How to Reduce your Risk of Cancer
Traditional medical treatments for cancer may include surgery, radiation therapy, chemotherapy, and hormone therapy. Many doctors use a combination of methods in an effort to increase the effectiveness and speed at which they attack the cancer. The treatment or combination of treatments is often dependent on the type, location, and severity of the cancer. While all of these therapies have been used with varying degrees of success - NONE OF THEM address the main problem with cancer - TOO MANY PEOPLE GET CANCER!
What is the ultimate solution to cancer? What should YOU be focused on?
How about not getting sick in the first place!
If given a choice, would you rather take a few simple steps to avoid cancer or do you want to take your chances and fight it once your doctor tells you you've got it? Would you rather spend your retirement money on the latest creative treatments and expensive high-tech equipment or spend time with the ones you love doing the things you love the most?
Just how much does our cancer crisis cost you? Consider that every man, woman and child in the U.S. contributes nearly $720 each year - that's almost $3,000 for a family of four! That number was calculated by taking the total health care cost of cancer and dividing it by the total U.S. population. No tricks. No funny money games. What could your family do with that $3,000 today?
Why spend hard earned money on treatments that often impact our quality of life? Many of the therapies for cancer are so physically debilitating that patients are often not able to return to work or do daily tasks around the house. People with cancer often require family members to help with the basic necessities of life, including getting dressed, taking a bath, and going to the bathroom.
Just as with heart disease, there are VERY SIMPLE lifestyle changes that you can start doing today that can decrease you risk of developing cancer. These same simple changes can also improve your overall quality of life. Ready? Here's the list:
1. Don't use any tobacco products. Don't smoke. Don't chew. Don't puff. Smoking is responsible for 90% of all cases of lung cancer. Want to drop your chances of contracting lung cancer to 10%? It's simple....don't smoke, chew or puff.
2. Protect yourself from the sun. Skin cancer is one of the most common forms of cancer yet it is the MOST PREVENTABLE. Avoiding peak sunlight (between 10am and 4pm), wearing sunscreen, and avoiding tanning beds and sunlamps can virtually eliminate the risk of skin cancer.
3. Maintain a healthy weight. There is a direct relationship between excess body weight and those that die of cancer. The American Cancer Society found that the more overweight you are, the greater your risk of dying from cancer.
4. Keep your immune system working properly. Cancer cells appear in our body every day, but our immune system knows how to recognize an unhealthy cell and eliminate it. Our central nervous system plays a major role in the function of our immune system so anything we can do to strengthen our central nervous system will reduce our risk of cancer. Two key ways to keep our central nervous system operating at peak performance is spinal alignment (yep, go see the chiropractor) and eating nutrient dense foods. Studies have found that this one-two punch increases the amount of antibodies within your system within minutes after a spinal adjustment or consuming a nutrient dense supplement.
5. Exercise on a regular basis. Physical activity is one of the primary methods of maintaining your ideal weight and in keeping your body's organs, tissue, muscle, ligaments, and bones strong and healthy.
6. Eat nutritionally dense meals and supplement. Eat lighter and leaner by choosing to eat fewer high-fat foods. High fat diets may increase your risk of prostate, colon, rectum and uterus cancer. Supplement with nutrient dense supplements that are made from nutrient dense plants such as aloe vera and sea vegetables.
7. Think healthy. Studies have shown over and over again that reducing stress will reduce the risk of cancer AND heart disease. Take time out of your day, better yet, plan each day to remove stress. Stress weakens cells, weak cells makes the body more susceptible to developing cancer.
That's it. Seven of the easiest steps you can do today to reduce your risk of cancer. To make them really work for you, learn a bit more about each. There is plenty of information about exercise, nutritional supplements, reducing stress, losing weight, etc. Learn more, do more, and choose to NOT be one of the million plus people diagnosed with cancer each year.
Some Facts About Asbestos
While tracing the history of asbestos it was found that its usage dates back to 2000 years. The name 'asbestos' was first used by the Greeks, which meant 'inextinguishable'. Though the Greeks also noted the harmful effect of asbestos, yet they did not pay any heed to its dangers because according to them it had magical powers that had to be used to fulfill the daily purposes of life. The Roman naturalist Pliny and the Greek geographer Strabo also noted the devastating effect of asbestos on human beings but they did not arise any questions considering its several magical uses in their regular life.
Some Facts about Asbestos
What is Asbestos?
Asbestos is the term given to a collection of six naturally occurring minerals that are incombustible and separable into filaments. These six minerals are chrysotile, amosite, crocidolite, anthophyllite, termolite and actinolite. Among these six asbestos minerals, the first three are abundantly used in manufacturing of industrial and commercial products.
Uses of Asbestos
Asbestos was being used since ancient Greek times and its usage continued till 1700, but it was popularized after the Industrial Revolution. It was used in construction mainly in steel pipes, industries, steam pipes, hand held hair dryers to prevent over heating, household items and in several other industries for various purposes.
Versatility of Asbestos
The reason for the popularity of asbestos was its power of resistance to electricity and its fire and heat proofing capacities. Being a fireproof or incombustible material, asbestos is impervious to every weather effect. This high tensile strength and flexibility makes asbestos very versatile for usage in various products and industries.
Diseases caused by Asbestos
One of the deadliest diseases caused by asbestos is mesothelioma cancer. It has become a threat to human civilization causing pain, suffering and loss of thousands of lives. The mortality rate is so high that eight out of ten mesothelioma patients pass away even before the treatment starts. It is a deadly cancer caused mainly to those who are exposed to asbestos in some way. The other deadly disease caused by asbestos is asbestosis, a serious form of lung illness. The main symptoms of asbestosis are short breath after exercise or exertion, dry prolonged cough, general malaise or feeling tired and wheezing.
Treatment of Diseases caused by Asbestos
Being a form of cancer, all the traditional cancer treatments are applied to treat mesothelioma. Surgery for cutting out the affected part of the lungs, chemotherapy to attack the cancer cells; or radiation to kill the cancerous cells are the only treatments for mesothelioma cancer. However, newer and better modes of treatments are being worked out to help mesothelioma patients. Diagnosis for asbestosis is necessary in its early stage as prolonged asbestosis can turn into mesothelioma cancer later in life. Regular intake of the prescribed medicine and check-up can help a lot. But the life span decreases on its own as the disease is diagnosed a long time after exposure to asbestos. Legal
Claims for Asbestosis and Mesothelioma
An asbestosis or mesothelioma legal claim can be filed on your behalf if your disease is caused by exposure to asbestos. An attorney will investigate how much asbestos containing material you were exposed to, who were the employers and what proper safety measures were taken for your health. This claim can be made against the construction company, the asbestos suppliers and even the individuals who were responsible to look after your health safety.
Asbestos- an Ancient Link to Deadly Mesothelioma
Asbestos has been used since the times of the Ancient Greeks, but its dangers are a modern-day issue. Asbestos was used often in the nineteenth and twentieth centuries because of its high tolerance to heat and its usefulness in fireproof insulation. However, recently it has been exposed that when inhaled, asbestos causes deadly lung conditions such as mesothelioma.
Occupational Exposure and Dangers To Workers
After noticing that chronic diseases, especially cancers of the lung such as mesothelioma, were extremely common in construction workers who were exposed to asbestos, doctors began making a connection between asbestos and mesothelioma. Unfortunately, construction and other workers who were exposed to asbestos from the 1950s through the 1970s, when the dangers of asbestos were more fully recognized, are still suffering from the ill effects of asbestos exposure at work. There are now laws and regulations in place that are designed to prevent workers from exposure to toxic asbestos; however, these laws cannot undo years upon years of exposure to this deadly mineral in the workplace.
Delayed Diagnosis Due To Long Dormancy Period
Workers may have been exposed to asbestos in the 1970s, but may only just now be developing the tell-tale symptoms of mesothelioma. Mesothelioma is slow to appear which causes doctors to have a hard time diagnosing and treating patients with the disease in time. Because symptoms of mesothelioma don't show up for many years after exposure and are similar to symptoms for other diseases, workers with mesothelioma might be misdiagnosed during the early stages of the disease.
Symptoms of mesothelioma include:
* shortness of breath;
* abdominal swelling;
* pain of the abdomen;
* blood clotting problems;
* chest pain;
* chronic cough;
* heart palpitations;
* fever;
* labored breath;
* weight loss.
Pleural, peritoneal and pericardial mesothelioma are all possible variations of the deadly cancer, with pleural (lung) mesothelioma the most commonly manifested version of the disease.
High-Risk Professions
Though the use of asbestos is now regulated by laws and regulations, the disease's long dormancy period means that it still has a high number of potential victims. Professions at a high risk for asbestos exposure and mesothelioma are those which involved repeated exposure to asbestos in its industrial forms. These professions include:
* electricians;
* painters;
* insulators;
* carpenters;
* bricklayers;
* construction workers;
* mechanics;
* other tradespeople, in particulal, people who worked in home or commercial construction prior to the 1970s.
Other people at risk for getting mesothelioma are the families of people who worked with asbestos because the dust may have settled in the employee's hair or clothing.
Legal Options
Because of the huge number of potentially affected workers, there has been a significant amount of litigation against companies who irresponsibly used asbestos, exposing their workers to the threat of mesothelioma and other life-threatening asbestos-related illnesses. It is essential to consult your doctor to discuss a treatment plan if you are suffering from exposure to asbestos. Then contact an asbestos attorney who is experienced in mesothelioma litigation. A competent asbestos lawyer may be able to help you recover damages for the pain and suffering incurred through asbestos exposure and mesothelioma, defray the costs of treatment, and provide for your children if you die of the disease.
Who Is At Risk of Asbestos Exposure?
Asbestos exposure can cause a variety of health problems, most notably mesothelioma. Mesothelioma is a rare form of cancer that attacks the membranes lining the chest and abdomen. Exposure to asbestos can also cause asbestosis, a disease that causes lung damage and can lead to serious breathing problems. Asbestos is a naturally occurring fiber, and everyone is exposed to asbestos at some point. The key is to know if you're at risk for prolonged and repeated exposure that can seriously affect your health.
Because asbestos has been known to be dangerous for several decades, government regulations have lessened the risk of everyday exposure. Still, millions of people have been exposed to dangerous amounts of asbestos. Asbestos has been used in the manufacture of various materials such as insulation and factory equipment. Anyone who has been involved in the mining of asbestos is at risk for exposure. Workers who have processed asbestos or manufactured products involving asbestos are also at great risk for exposure. Those who have worked in the construction industry laying insulation, putting up or removing drywall, or removing from or demolishing buildings may be exposed to risky levels of asbestos. Others possibly affected include firefighters and anyone in the automobile manufacturing industry.
Most recently, relief and cleanup workers who worked at the site of the World Trade Center attacks in 2001 were exposed to serious amounts of asbestos. Hundreds of tons of asbestos that was used in the manufacture of the buildings were released into the air, putting everyone in the area at risk. Many of those present at the time have shown symptoms of asbestos-related disease and breathing problems. Because mesothelioma may not develop until decades after exposure, it is not yet known how many were affected.
The families of workers who are exposed to asbestos may also be at increased risk. Those who work with asbestos may bring the fibers home on their bodies or clothes. The government regulates this possibility by requiring that workers who are exposed to asbestos shower and wash their work clothes before leaving work. Still, asbestos fibers may find their way home with the workers.
If someone meets any of these criteria, it's important that they get checked regularly for possible asbestos-related health problems. Early detection is one of the keys to recovery from diseases such as cancer, and understanding your risks of asbestos exposure will help you prevent asbestos-related health problems.
Human Papilloma Virus and Cancers
In recent years, it has become clear that certain types of human cancers have a viral component to their etiology. Cancers due to Human Papilloma Virus (HPV) are most common among these. This has been a study of intense research for number of years. Specific types of HPV genotypes were found to be the causative agents of some common cancers, most notable invasive cervical carcinoma. Apart from this anogenital cancer, HPV’s are also causally associated with other anogenital cancers such as cancers of vulva, vagina, penis and anus. HPV is also responsible for approximately 20-30% of head and neck cancers [1].
Association OF HPV with Cervical cancer
The link between HPV and cervical cancer is now established beyond doubts. Many epidemiological [2], [3] and molecular evidences [4] suggest the causal association of HPV’s with cervical cancer. It has been estimated that about 500,000 women acquire cervical cancers every year and 75% of this are from developing countries. In United States about 13000 cervical cancer cases are diagnosed every year and about 7000 deaths annually from prevalent disease [5].
Evidence suggests that the great majority of all grades of cervical intraepithelial neoplasia can be attributed to cancer-associated types of HPV infections [3]. It has been estimated that only about 10% of the HPV patients would develop cervical dysplasia and of these only few people would develop cervical cancer. Studies conducted on HPV DNA in a variety of genital lesions suggested that HPV types 16 and 18 are most closely associated with risk of genital cancers [4] and some of HPV types are considered to be more prevalent among cervical cancer patients in a specific geographical areas; HPV 45 in Western African [6].
The development of cervical cancer is associated with factors other than just high risk HPV infection. Factors like impaired cell mediated immunity, long term use of contraceptives and smoking also increase the risk of gaining and the persistence of HPV types which in turn may lead to cervical cancers [7],[8].
Association of HPV with other anogenital cancers
Strong links between HPV and anogenital cancers such as penile, anal, vulvar cancers have been demonstrated by many studies. These cancers are formed from lesions develop in the vagina, vulva, penis and anus as the result of sexual contact [9]. But the exact role of HPV in the natural history of anal squamous intraepithelial lesions is still unknown [10].
Studies indicate that about 1% of sexually active adults in the United States show visible genital wart and about 15 % have sub clinical infection. The most commonly detected HPV types were found to be HPV 16 and 18 [11]. But, HPV types 56, 59-64 and 71 also have been isolated in vulvar intraepithelial neoplasia [12] .
Association of HPV with head and neck cancer
The term head and neck cancer refer to the cancers in the oral cavity, lip, nose, para nasal sinuses, naso-pharynx, oro-parynx, larynx, oesophagus, salivary glands, soft tissues of the neck and ear. Oral cancer is the sixth most prevalent cancer worldwide and about 620,000 patients are diagnosed with cancer of oral cavity every year [13]. Many studies have found evidence suggestive of a role for human papilloma virus in head and neck cancer [14],[15]. Though the exact mode of transmission of HPV infection in the head and neck region has not been determined, it’s association with sexual behavior and perinatal transmission have been demonstrated [16].
During the pathogenesis of HPV, it enters to the host through the mucosal epithelial layer surface. Oral mucosa resembles the mucosa of the genital region in their histological structure. As the correlation between HPV and cervical cancer are well established, the resemblance of the mucosal histology led to the suggestion that HPV could play a role in the development of benign and malignant lesions of the oral mucosa [17].
After the first report of papilloma virus in tongue carcinoma[14], many studies have shown the presence of HPV DNA in oral cavity [15] and head and neck cancer [13]. The most prevalent HPV types in these were found to be HPV 16 and 18. Further epidemiologic and molecular investigation should be carried out to establish a precise relationship between HPV and head and neck cancer.
HPV INDUCED CANCER DETECTION
Detective measures to date have centered on screening programs for HPV induced cancers. The most common and the traditional way of screening for cervical cancer and cervical dysplasia are to conduct a pap smear test. This has significantly reduced the incidence of cervical cancers in recent years. If the result is turned out to be positive, then the colposcopy would be carried. Since cervical cancer and anal cancer resembles in their biological features, it has been observed that screening for anal high grade squamous intraepithelial lesions with anal pap smear allows detecting individuals at risk of developing anal cancers. To obtain a confirmatory result, an anoscopic examination should be performed [18, 19].
Detection of earlier stage of head and neck cancers as well as premalignant lesions can be done by regular physical examinations by the doctor. Any abnormalities should be further evaluated. An endoscopy is performed on the samples obtained from throat, larynx, and upper esophagus. Computed tomographic (CT) scans, magnetic resonances imaging (MRI) scans or ultrasounds could be performed to identify the size and extent to which the cancer has spread from its site of origin [20].
No standard screening tests are followed for vulvar cancers. In vulvar cancer lymph node pathologic status is the most important predictive factor. A study conducted by De Ceccoc et al indicated that Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance are easy and reliable methods for the detection of sentinel node in early vulvar cancer [21]. Coloscopy can also be used to detect abnormalities on vulvar epethilia [19].
The above mentioned tests cannot be used to detect the presence or absence of the virus which would eventually cause a cancer. A test based on the hybrid capture technologies is now available to detect 13 cancer causing kinds of HPV. This technology is based on the principle of signal amplification of a hybrid species produced by RNA probes fixed with HPV DNA [22]. Polymerase chain reaction is one of the most sensitive tests for HPV DNA detection [23]. But Zhao M. et al suggest that there could be limitations in this method when applying to a broad population [24]. Studies indicate that HPV DNA testing is one of the most effective tests which could be used for the prevention of cervical cancer [25].
In a study conducted by Reid et al, to compare the efficacy of cervical cytology, cervicography and/or DNA hybridization for cervical cancer screening, showed that none of the tests succeeded in identifying all the abnormalities [26].
REFERENCES
1. I. Benjamin Paz, N.C., Tamara Odom-Maryon, Yuan Xie, Sharon P. Wilczynski,, Human papillomavirus (HPV) in head and neck cancer. Cancer, 1997. 79(3): p. 595-604.
2. Koutsky, L.A., et al., A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med, 1992. 327(18): p. 1272-8.
3. Schiffman, M.H., et al., Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst, 1993. 85(12): p. 958-64.
4. JC Macnab, S.W., JW Cordiner, and JB Clements, Human papillomavirus in clinically and histologically normal tissue of patients with genital cancer. The New England Journal of Medicine, 1986. 315(17): p. 1052-1058.
5. Parkin, D.M., P. Pisani, and J. Ferlay, Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer, 1999. 80(6): p. 827-41.
6. Bosch, F.X., et al., Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst, 1995. 87(11): p. 796-802.
7. Calore, E.E., S.M. Pereira, and M.J. Cavaliere, Progression of cervical lesions in HIV-seropositive women: a cytological study. Diagn Cytopathol, 2001. 24(2): p. 117-9.
8. Brisson, J., et al., Risk factors for cervical intraepithelial neoplasia: differences between low- and high-grade lesions. Am J Epidemiol, 1994. 140(8): p. 700-10.
9. Jung, W.W., et al., Strategies against human papillomavirus infection and cervical cancer. J Microbiol, 2004. 42(4): p. 255-66.
10. Palefsky, J.M., et al., Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer. Cancer Res, 1991. 51(3): p. 1014-9.
11. Koutsky, P., Laura, Epidemiology of Genital Human Papillomavirus Infection. The American Journal of Medicine, 1997. 102(5, Supplement 1): p. 3-8.
12. Longuet, M., S. Beaudenon, and G. Orth, Two novel genital human papillomavirus (HPV) types, HPV68 and HPV70, related to the potentially oncogenic HPV39. J. Clin. Microbiol., 1996. 34(3): p. 738-744.
13. Syrjanen, S., Human papillomavirus (HPV) in head and neck cancer. J Clin Virol, 2005. 32 Suppl 1: p. S59-66.
14. de Villiers, E.M., et al., Papillomavirus DNA in human tongue carcinomas. Int J Cancer, 1985. 36(5): p. 575-8.
15. Palefsky, J.M., et al., Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. J Oral Pathol Med, 1995. 24(5): p. 193-7.
16. Szentirmay, Z., et al., Human papillomavirus in head and neck cancer: molecular biology and clinicopathological correlations. Cancer Metastasis Rev, 2005. 24(1): p. 19-34.
17. Woods, K.V., et al., Analysis of human papillomavirus DNA in oral squamous cell carcinomas. J Oral Pathol Med, 1993. 22(3): p. 101-8.
18. Sheary B, D.L., Cervical screening and human papillomavirus. Aust Fam Physician., 2005. 34(7): p. 578-80.
19. JD., O., Genitoanal papillomavirus infection--a diagnostic and therapeutic dilemma. Semin Dermatol., 1990. 9(2): p. 141-7.
20. Antunes, J.L.F., et al., Trends and spatial distribution of oral cancer mortality in Sao Paulo, Brazil, 1980-1998. Oral Oncology, 2001. 37(4): p. 345-350.
21. C De Cicco, M.S., M Bartolomei, C Grana, M Cremonesi, M Fiorenza, A Maggioni, L Bocciolone, C Mangioni, N Colombo and G Paganelli, Sentinel node biopsy in early vulvar cancer. British Journal of Cancer, 2000. 82: p. 295-299.
22. Thomas, R.J., Early Detection of Cervical Cancer -New diagnostics identify HPV. Modern Drug Discovery, 2000. 4: p. 57-58.
23. Miller CS, Z.M., White DK., Detection of HPV DNA in oral carcinoma using polymerase chain reaction together with in situ hybridization. Oral Surg Oral Med Oral Pathol., 1994. 77(5): p. 480-6.
24. Ming Zhao, E.R., Andre Lopes Carvalho, Wayne Koch, WeiWen Jiang, David Sidransky, Joseph Califano,, Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. International Journal of Cancer, 2005. 117(4): p. 605-610.
25. Denny, L.A., Human papillomavirus testing and screening. Best Practice & Research Clinical Obstetrics & Gynaecology, 2005. 19(4): p. 501-15.
26. Harry, T.C.S., K.M., Evaluation of the Hybrid Capture human papillomavirus deoxyribonucleic acid detection test. American Journal of Obstetrics & Gynecology, 1996. 175(3): p. 758-9.
Asbestos Litigation in California
California asbestos laws have changed over the past few years, showing more favor toward the side of companies that have violated California asbestos laws prior to the year 1980.
Asbestos litigation has taken on a whole new meaning as lawyers have had to take on this new specialty and grow into asbestos lawyers. What does all this mean for California residents in need of asbestos litigation?
It means that the lawsuit being filed by California based asbestos lawyers are under a more scrutinous attack, which mean the time to enter into an asbestos lawsuit in the state of California is now.
Asbestos lawyers recommended a consultation for any individual who has been exposed needlessly to asbestos, even if they have not yet been diagnosed with Mesothelioma, the cancer specifically caused by asbestos exposure.
Filing asbestos litigation cases prior to determining that the exposed victim is ill is not uncommon. This is done to protect the rights of the victim while the California asbestos laws allow for a tolerable and reasonable settlement, as California asbestos laws change often enough to complicate cases in the future.
Of course, victims with open and shut cases will always have some favor in the eyes of California asbestos laws, but open and shut cases are harder and harder to come by. Most asbestos litigation isn't as simple as it seems. Often people were employed by more than one company within their working lifetime and proving that the asbestos exposure that is prompting the asbestos litigation came from any one particular company is not always simple.
Many companies who have experienced asbestos litigation understand the penalties for intentionally or negligently exposing their employees to asbestos, and have chosen unscrupulous routes to avoid ending up in any additional asbestos litigation.
California asbestos law is complex and requires an expert to help decipher it. It is important for those considering pursuing asbestos litigation to get the professional counsel that an asbestos lawyer can offer.
Asbestos lawyers are up to date on all the changes in California asbestos law and can help those who were needlessly exposed to asbestos understand their rights within the realms of the ever changing California asbestos laws. Naturally, the entire state of affairs is completely unfair, and people need to understand that while companies may be empathetic to a victim's plight, most companies by now have changed hands, or at least management, and are now also trying to protect the rights of the current workforce, even if that means allowing a Mesothelioma victim flounder in their pain, suffering, and exorbitant medical bills.
This is of course unfair to those who worked tirelessly for these companies in the past, and it is a fine ethical line for the companies of the present to find a middle ground to protect all employees, past, present, and even future.
California asbestos laws are not the only asbestos laws which have undergone change over the past few years. Asbestos lawyers all over the country are having to fight harder for victim's rights. However, in most cases, these victims are still receiving fair judgments and settlement offers, at least for now.
There have been asbestos litigation cases that have been filed on behalf of those who are not sick and may or may not become ill in the future, however the threat that asbestos exposure brings with it is often enough to enter into asbestos litigation. It takes a talented asbestos lawyer, one who is on top of every change in California asbestos laws, to complete these premature examples of asbestos litigation, however the claims are still very legitimate.
The best advice an asbestos lawyer can offer anyone wondering if they qualify for asbestos litigation under the current California asbestos laws is to receive a consultation. Most asbestos lawyers will in fact meet with a client with a potential claim free of charge in order to determine if the information provided is adequate for entering into asbestos litigation.
A consultation can place the minds of potential and actual victims at ease as they attempt to make decisions about their future. Asbestos litigation is a complex field, and not every average attorney can truly handle the specified laws that relate to asbestos cases.
Just as a victim of road rage would not hire an asbestos lawyer, victims of asbestos exposure should not hire an attorney not equipped to handle the intricate California asbestos laws associated with asbestos exposure in the state of California. It is of course, common sense.
The Facts About Asbestos Exposure
Knowing the facts about asbestos exposure will help you to protect yourself and your loved ones. The U.S. and many other governments have compiled fact sheets and created guidelines and laws for handling and reporting asbestos exposure, as well as strict guidelines for asbestos removal and abatement. Being informed about asbestos and the dangers of asbestos exposure can help you avoid becoming a statistic.
Why Asbestos Exposure is a Problem
The danger of asbestos exposure arises from inhaling and swallowing tiny dust particles and fibers. Those particles are released when asbestos is broken up or disturbed in anyway. Once the asbestos fibers have been inhaled or swallowed, they may lodge in the lining around the lungs, heart or abdominal cavity and go unnoticed for decades.
Eventually, though, they cause scarring and cell changes that can become a malignant cancer known as mesothelioma. Even when mesothelioma does not develop, asbestosis and other asbestos related conditions can cause pain, restricted breathing and other difficulties.
How Asbestos Exposure Happens
There are many ways to be exposed to asbestos, but the most common type of asbestos exposure is occupational, or work related. Asbestos was used in the construction industry, the auto industry, on the railroads and in shipyards and in many factories that made items coated with or woven with asbestos.
When the asbestos was broken, moved, sanded, poured or otherwise manipulated, fine particles and dust was released into the air, where it was inhaled and swallowed. Family and household members of people who worked with asbestos were also often exposed to the dust when it was carried home in clothing and hair.
People who lived in the vicinity of asbestos plants may have been exposed to asbestos in the environment. According to the Agency for Toxic Substances and Disease Registry, residents who lived near asbestos plants may have been exposed to asbestos by breathing the air within a few blocks of the plant, playing in waste piles of rock near the factories and moving or handling waste rock from processing plants.
In addition, there is a significant risk of exposure to asbestos in some older buildings where asbestos laced materials were used in construction. These materials are safe as long as they are covered and/or in good condition. However, asbestos may be disturbed during renovations, demolition or when flooring, ceilings and walls become damaged.
How to Protect Yourself from Asbestos Exposure
Although the use of asbestos in new products is now heavily regulated, there are still ways that you might be exposed to asbestos. If your home was built before 1978, for instance, it likely contains many materials that were made with asbestos.
Most of these materials only become a concern when they are disturbed or start to decay. Asbestos exposure can become a significant risk if you are renovating or dealing with the aftermath of a flood, fire or other event that damaged your home. If you're not certain about materials in your home that may contain asbestos, it's best to contact your local town offices or health department to find out about having your home evaluated for asbestos and what sort of asbestos abatement regulations apply in your area.
What You Can Do If You Believe You Were Exposed to Asbestos
Mesothelioma affects thousands of people every year. Because its earliest effects are often mistaken for the symptoms of a cold, virus or flu, it's often not diagnosed until it has progressed beyond the treatable stage.
For that reason, anyone who worked or works in a job with a high risk of asbestos exposure should have regular medical checkups that include lung x-rays, and be especially watchful for respiratory ailments which may be the earliest symptoms of mesothelioma.
In addition, when asbestos exposure combines with smoking, your risk of developing lung cancer increases astronomically. If you were exposed to asbestos in the past and you smoke, quitting now can significantly reduce your chances of developing lung cancer.
Why Asbestos Exposure is a Legal Issue
Asbestos was one of the most widely used industrial minerals through the early to mid 1970s. The companies that mined, distributed and used asbestos were very aware of the danger that asbestos posed to their workers.
Instead of warning them and providing for safer handling, the industry deliberately hid those dangers from the public, their workers and the government. In doing so, they callously exposed hundreds of thousands of workers and their families to a deadly carcinogen.
Because these companies were aware of the dangers of asbestos and did nothing to warn or protect their workers intentionally, they may be legally liable for compensating people who became ill because of asbestos and their families.
If you believe that you or a family member became ill because of asbestos exposure, a law firm experienced in handling asbestos-related cases can evaluate your claim and help you get the compensation you deserve for your loss.
California Asbestos Lawyers Representing Thousands
Asbestos litigation and mesothelioma lawsuits are on the rise once again in California. Thankfully, there are top notch, eager asbestos lawyers ready to handle the workload as mesothelioma victims are coming by the thousands in search of their day in court. Mesothelioma lawsuits are now one of the fastest growing medically based lawsuits bracket in California, a perfectly preventable tragedy.
California asbestos laws have attempted to make mesothelioma lawsuits harder to file, but the evidence can not be swept under the rug and asbestos lawyers are proving time and again that the American dream was flushed down the hall of hopes with big business taking callous and careless attitudes toward the dutiful employees that made them wealthy.
California asbestos laws can't hide the negligence, and asbestos lawyers are fighting on behalf of victims and their families to prove this. Asbestos litigation is nothing new. The first filing of a mesothelioma lawsuit dates all the way back to the 1930's. It would have made sense for big business to have addressed their asbestos problems by now, or perhaps it is way past time for tougher California asbestos laws for asbestos neglect by businesses and corporations.
With the history of mesothelioma lawsuits and asbestos litigation, it would have made sense for California asbestos laws to require more stringent bans on the use of asbestos and higher standards for company policies involving employee protection. However, asbestos is still in use today, granted in smaller amounts, but still at high enough concentrations to cause more mesothelioma lawsuits in the future.
If California asbestos laws would impose a ban on asbestos and require asbestos removal, the health of California employees would simply no longer be at risk. It's just logical.
Asbestos litigation and asbestos lawyers are hard at work presenting this logical thought process to juries throughout the state. Jury awards in asbestos litigation tends to run very high, as asbestos lawyers have been able to impress upon juries how simple and cost effective it would have been for companies with asbestos exposure problems to protect their employees.
Juries, who are typically average hardworking individuals themselves, understand the insanity of being in a situation that requires a mesothelioma lawsuit, and often have had enough of big business practices which do not consider employee health or well being.
Thus businesses that are guilty of asbestos exposure are likely to run into numerous mesothelioma lawsuits in the near future. Mesothelioma lawsuits are the only voice that a mesothelioma victim has against the company that negligently contributed to their illness and asbestos lawyers are their very necessary mouthpiece.
Asbestos lawyers have sent eh detrimental nature of mesothelioma, and are fighting diligently both in the courtrooms of California as well as in the California legislature to hopefully amend California asbestos laws to work more in favor of harsher discipline for violators of asbestos safety requirements, as well as to tighten the belt of requirements as soon as possible.
While asbestos is a fire retardant, there are now newer and safer materials that can do the job of asbestos, although granted not as cheaply. California asbestos laws are too lenient on the use of asbestos as well as violators of current California asbestos laws. It takes a very good asbestos lawyer to fight this battle in full flair, but the necessity of the fight can no longer be denied.
Mesothelioma victims who file mesothelioma lawsuits do so in order to protect their family's financial future, to help offset the astronomical costs of mesothelioma treatments, and to heighten awareness of asbestos related illness and their ability to be prevented.
It is senseless that a lifetime of service to a company and a dedication that employees have shown end up in a courtroom fighting a mesothelioma lawsuit, and in a hospital room fighting a mesothelioma prognosis.
Every human being has the right as a human to be treated with respect of health and well being. There truly is no excuse for asbestos exposure in our age of technological advancements and our ability to produce safer and more effective fire resistant materials.
Perhaps it will take more than a few dedicated asbestos lawyers and mesothelioma lawsuits and asbestos litigation to drive these points home and change California asbestos laws, but it the place we have to start. With the dedicated expertise and the heart of the victims, California asbestos laws are bound to face changes one day.
Unfortunately for the thousands in California alone who are already affected by mesothelioma and asbestos related disease, someday did not come soon enough.
|
|
|